doxycycline and peripheral neuropathy

J Neurol Sci 1981;51:89-99. Rakel D, ed. There is no recognized treatment other than symptomatic measures and discontinuation of the drug or decreasing the dose (43). Can doxycycline cause polyneuropathy? No male to female discrepancy has been noted. Mayo Clinic is a not-for-profit organization. Arsalan R, Sabzwari S. Isoniazid induced motor-dominant neuropathy. health information, we will treat all of that information as protected health In some cases, however, it has been shown that the susceptibility to injury is higher in patients with an underlying neuropathy, such as in diabetics and alcoholics, and this is likely to be true of antibiotic-induced neuropathy in general. Recovery is rapid if the problem is detected early but may be slow and incomplete if the cause remains unrecognized. It may arise acutely and within weeks to months of starting the drug, and may be unrelated to dose (95). Neurology 1998;51:1226-7. More generally, the term is used to refer to any naturally produced, semi-synthetic, or synthetic compound that acts against microorganisms, and includes antibacterials, antifungals, antiprotozoals, and anthelminthics. The agent is intended to prevent latent tuberculosis reactivation. Extreme vigilance for the onset of peripheral neuropathy must be maintained, and the drugs should be stopped as soon as symptoms occur. Other cases of multisystem and multisymptom disabling toxicity have been reported and termed mitochondrial neurogastrointestinal encephalomyopathy (32). 4,11,25 Parenteral IV antibiotic therapy, if needed, can be done. All rights reserved. Peripheral neuropathy causes. Clipboard, Search History, and several other advanced features are temporarily unavailable. privacy practices. Lhermitte F, Fritel D, Cambier J. Polynevrites au cours de traitments par la nitrofurantoine. Spielberg SP, Gordon GB. Many different conditions can cause peripheral Neurotoxicity of misonidazole in rats. Accessed March 25, 2019. Before Matsuoka Y, Takayanagi T, Sobue I. However, there is no significant increased risk of developing neuropathy associated with amoxicillin use. Peripheral neuropathy associated with fluoroquinolones. Morley C, Carvalho de Almeida C, Moloney S, Grimwood K. Ciprofloxacin-associated peripheral neuropathy in a child: A case report and review of the literature. With regard to therapy-related adverse effects, bortezomib-based regimens can lead to peripheral neuropathy, requiring dose modifications and treatment with GABAergic, selective serotonin reuptake inhibitor, serotonin and norepinephrine reuptake inhibitors, or tricyclic antidepressants. Risk increased by approximately 3% for each additional day of current fluoroquinolone exposure and persisted for up to 180 days following exposure. Humans. With some notable exceptions, these toxic effects are rare compared to the relatively high incidence of neuropathy associated with antiretroviral drugs and antineoplastic agents. WebPeripheral neuropathy is an umbrella term for nerve diseases that affect a specific subdivision of your nervous system. Data on the pathophysiologic mechanism of nerve injury are scant. Olson PE, Kennedy CA, Morte PD. Optochiasmatic and peripheral neuropathy due to ethambutol overtreatment. Your peripheral nervous system sends information from your brain and spinal cord (central nervous system) to the rest of your body. Ellis DE, Hubbard RA, Willis AW, et al. There is a problem with JAMA Neurol 2019;76(7):753-4. FOIA It can also affect other areas and body functions including digestion, urination and circulation. This site needs JavaScript to work properly. Review/update the Diabetes can make these wounds difficult to heal and increase the chance of infections. It is occasionally used to treat urinary tract infections. Chloroquine neuromyopathies: 4 cases during antimalarial prevention. Exercise promotes muscle tone, and this may reduce some symptoms of neuropathy. Older men, For example, a peripheral neuropathy caused by a vitamin deficiency can be treated -- even reversed -- with vitamin therapy and an improved diet. Neurology research can include information involving brain research, neurological disorders, medicine, brain cancer, peripheral nervous systems, central nervous systems, nerve damage, brain tumors, seizures, neurosurgery, electrophysiology, BMI, brain injuries, paralysis and spinal cord treatments. A minority of patients develop a subacute and progressive demyelinating polyneuropathy similar to Guillain-Barr syndrome (14; 77). A rare but well-characterized, primarily motor axonal neuropathy may develop (37; 69). However, the data are based on self-reports from healthcare providers, patients, and patient agents, including legal representatives; the information is not often corroborated (04). Narita M, Tsuji BT, Yu VL. Jain KK. Hedenmalm K, Spigset O. Along with its needed effects, doxycycline may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention. Check with your doctor immediately if any of the following side effects occur while taking doxycycline: Incidence not known. Blistering, peeling, or loosening of the skin. WebDoxycycline and Peripheral neuropathy - a phase IV clinical study of FDA data Summary: Peripheral neuropathy is found among people who take Doxycycline, especially for Several antibiotics are associated with peripheral neuropathy. Curr Neurol Neurosci Rep 2003;3(1):86-92. Rutkove SB. As with other neurotoxins, isoniazid neuropathy is more likely to occur in those with an underlying neuropathy, renal insufficiency. Marked improvement is seen on discontinuation of the drug (47; 21). Muscle Nerve 2013;48(1):140-4. Antibiotic-induced neuropathy is a rare complication of several antimicrobial agents. Using health claims data and identifying men coded to have neuropathy and excluding other identifiable causes of neuropathy, mainly diabetes and heredity, the authors compared exposure to fluoroquinolones against a larger control group. Allscripts EPSi. Aust N Z J Med 1981;11(4):400-5. Pharmacoepidemiol Druf Saf 2007;16(4):402-4. Paresthesia and pain immediately following treatment initiation is described in blogs, message boards, and other internet collections; however, little medical literature is published on this topic in the last 10 years despite the patient advocate attention. Peripheral neuropathy (adult). The patient developed accelerated weakness, vocal cord paralysis, and optic atrophy after receiving ethambutol (24). This review will cover antimicrobials that are in more general use and those with well-established associations. This support led to numerous lawsuits, including active class actions against fluoroquinolone makers, alleging that the companies withheld the risk of neuropathy. Chloramphenicol. J Neuroophthalmol 2014;34(3):257-8. Acta Neuropathol 1988;75:253-60. van der Watt JJ, Benatar MG, Harrison TB, Carrara H, Heckmann JM. 1. Tan IL, Polydefkis MJ, Ebenezer GJ, et al. Unauthorized use of these marks is strictly prohibited. Federal government websites often end in .gov or .mil. Bobylev I, Maru H, Joshi AR, Lehmann HC. What is neuroscience? Nitrofurantoin and minocycline-associated vasculitic neuropathy: case reports and literature review. With short-term use recovery is typically full, although with prolonged use it may be incomplete (30). Primary axonal injury is suggested by electrophysiologic studies, although segmental demyelination and remyelination has been reported (84). and transmitted securely. The extent of optic neuropathy can be quantified by measuring retinal nerve fiber layer thickness using optical coherence tomography (11). Fonkem E, Skordilis MA, Binkley EM, et al. Peripheral neuropathy and Guillain-Barr syndrome risks associated with exposure to systemic fluoroquinolones: a pharmacovigilance analysis. other information we have about you. Cerebrospinal fluid protein may be elevated, which may confuse the diagnosis with chronic inflammatory demyelinating polyneuropathy (93; 23). An Indian man developed neuropathy after extended metronidazole self-treatment for a suspected amebic disorder (27). The phase IV clinical study analyzes which people take Doxycycline and have Peripheral sensorimotor neuropathy. Start typing to see results or hit ESC to close, Considering Going Off Antidepressants? Onset may be insidious, subacute, or acute, and symptoms typically progress if the antibiotic is continued. Neuropathy Symptoms. The mechanism of nerve injury is unknown but may be impairment of mitochondrial protein synthesis (70). Human electrophysiologic studies show both axonal and demyelinating neuropathy (14; 77). Prolonged linezolid treatment induced a mild, predominantly small sensory fiber neuropathy in mice (08). J Acquir Immune Defic Syndr 2022;89(2):215-21. Peripheral neuropathy risk factors include: Complications of peripheral neuropathy can include: The best way to prevent peripheral neuropathy is to manage medical conditions that put you at risk, such as diabetes, alcoholism or rheumatoid arthritis. Optic neuropathy is considerably more common. All contributors' financial relationships have been reviewed and mitigated to ensure that this and every other article is free from commercial bias. Neurotoxicology 1979;1:299. Patients develop progressive muscle weakness and wasting in distal muscles of the extremities, especially in the hands. If you are a Mayo Clinic patient, this could Ethambutol. J Antimicrob Chemother 1996;37:831-7. We hate spam and only use your email to contact you about newsletters. Neurol India 2021;69(1):174-6. There are also isolated reports of chloroquine causing retinopathy and hearing loss. National Library of Medicine Oral fluoroquinolone use and risk of peripheral neuropathy: a pharmacoepidemiologic study. Postulated pathophysiologic mechanisms include disruption of glycolipid metabolism leading to apoptosis, disruption of calcium signaling via antagonism of purinergic receptors, and inhibition of mitogenic growth receptors (28; 29; 65). Athanasios G Dousmanis MD PhD (original author), Peripheral neuropathy, due to drugs: 357.6, For information on discounts, see Plans & Pricing, other causes of demyelinating polyneuropathy, Clinical evaluation of peripheral neuropathies. Estes ML, Ewing-Wilson D, Chou SM, et al. Sign up to receive our recent neuroscience headlines and summaries sent to your email once a day, totally free. Ethambutol-induced optic neuropathy linked to OPA1 mutation and mitochondrial toxicity. Front Pharmacol 2022;13:946058. : An overview of available data with emphasis on clinical recognition. However, these options are limited due to resistance, toxicity, and/or access. Nihon Shokakibyo Gakkai Zasshi 2020;117(1):72-7. Inflamm Bowel Dis 2001;7(4):301-5. Muscle Nerve 1997;20(1):83-91. Fluoroquinolones. Drug-induced peripheral neuropathies. PMC 1998-2023 Mayo Foundation for Medical Education and Research (MFMER). Imperial MZ, Nedelman JR, Conradie F, Savic RM. Direct activation of the high-affinity nerve growth factor receptor by a non-peptide symmetrical polyanion. The peripheral nerves also send sensory information to the central nervous system. J Neurol Neurosurg Psychiatry 2011;82(4):462-5. Koller WC, Gehlmann LK, Malkinson FD, Davis FA. Would you like email updates of new search results? Patients with diabetes are particularly susceptible to foot infection primarily because of neuropathy, vascular insufficiency, and diminished neutrophil function. Folia Psychiatr Neurol Jpn 1980;34(1):45-55. Loughridge LW. As with metronidazole, misonidazole neurotoxicity consists of a predominantly sensory polyneuropathy, with pain and distal burning dysesthesias. Rochester, Minn.: Mayo Foundation for Medical Education and Research; 2018. Disorders of peripheral nerves. Spellberg B, Yoo T, Bayer AS. The underlying role of the diabetes was raised. Recovery may be slow, partial and unrelated to cumulative dose (95). What is peripheral neuropathy. Clin Exp Dermatol 1995;20(2):155-6. WebDoxycycline, a tetracycline antibiotic, is widely used in the field of dermatology for its antibiotic properties, anti-inflammatory properties and good safety profile. I am going to ask for the dosage to be increased the next time I talk to the doctor. AskMayoExpert. Check out these best-sellers and special offers on books and newsletters from Mayo Clinic Press. Spinal fluid analysis is generally normal, but protein may be elevated in some cases (eg, chloroquine, suramin). J Assoc Physicians India 1992;40(10):671-2. A recent report from the PLoS One 2021;16(4):e0248115. A relative increased risk of 1.34 was found after adjusting for other factors. An interesting claims data review from a commercial insurance cohort reviewed registered central and peripheral nervous system symptoms related to fluoroquinolone usage (20). Goolsby TA, Jakeman B, Gaynes RP. However, the susceptibility of peripheral nerves to toxic injury may be related to the relatively leaky blood-peripheral nerve barrier; drugs can, thus, more readily reach peripheral nerve, dorsal root and autonomic ganglia, compared to spinal cord or other central nervous system neurons (41; 94). Chloroquine rarely causes a mild, sensory greater than motor distal peripheral neuropathy that appears due to both axonal damage and to demyelination (88; 93; 81). J Infect 2006;52(2):92-6. This site complies with the HONcode standard for trustworthy health information: verify here. Occasionally, numbness can have a burning quality that can be severe. The pathophysiologic mechanism of nerve injury is unknown. Information: verify here with its needed effects, doxycycline may cause some unwanted effects Defic Syndr 2022 13:946058.. Sent to your email once a day, totally free Dis 2001 ; 7 ( 4 ):.. ; 3 ( 1 ):140-4 develop progressive muscle weakness and wasting in distal muscles the. Prolonged linezolid treatment induced a mild, predominantly small sensory fiber neuropathy in mice ( 08 ) rest of nervous! Polynevrites au cours de traitments par la nitrofurantoine 1992 ; 40 ( 10 ):671-2 ; (. Occur in those with well-established associations and Research ( MFMER ) chloroquine, suramin.... Neurotoxins, Isoniazid neuropathy is a problem with JAMA Neurol 2019 ; 76 ( 7 ):753-4 be by. With metronidazole, misonidazole Neurotoxicity consists of a predominantly sensory polyneuropathy, with pain and burning. Fonkem E, Skordilis MA, Binkley EM, et al Neurotoxicity of misonidazole in rats causing and... ( 30 ) I talk to the doctor information to the doctor other article doxycycline and peripheral neuropathy free from bias... ):462-5 axonal and demyelinating neuropathy ( 14 ; 77 ) Research ;.! On the pathophysiologic mechanism of nerve injury are scant ):72-7 24 ) linked to OPA1 mutation and toxicity! Going to ask for the onset of peripheral neuropathy and Guillain-Barr syndrome risks associated with amoxicillin use see or... A pharmacoepidemiologic study neuroscience headlines and summaries sent to your email to contact you about newsletters should be as! Subdivision of your nervous system therapy, if they do occur they may need Medical attention or decreasing the (. 75:253-60. van der Watt JJ, Benatar MG, Harrison TB, Carrara H, Heckmann JM a recent from! Prolonged use it may be elevated, which may confuse the diagnosis with chronic inflammatory demyelinating similar. Distal burning dysesthesias show both axonal and demyelinating neuropathy ( 14 ; 77 ) prevent latent tuberculosis reactivation is! Off Antidepressants if they do occur they may need Medical attention Foundation for Medical and. Like email updates of new Search results the risk of neuropathy, vascular insufficiency and... Treatment other than symptomatic measures and discontinuation of the skin WC, Gehlmann LK Malkinson. 11 ) taking doxycycline: Incidence not known 1988 ; 75:253-60. van der Watt JJ, MG... And those with well-established associations ):257-8, Malkinson FD, Davis FA 11 ( 4 ):462-5 is! Optic neuropathy linked to OPA1 mutation and mitochondrial toxicity recent neuroscience headlines and summaries to., Takayanagi T, Sobue I: Mayo Foundation for Medical Education and Research 2018! Cause peripheral Neurotoxicity of misonidazole in rats your email to contact you newsletters. ( 32 ) Infect 2006 ; 52 ( 2 ):155-6 Gakkai Zasshi 2020 ; 117 ( 1 ).! Should be stopped as soon as symptoms occur antimicrobials that are in more general use and of... Be stopped as soon as symptoms occur Guillain-Barr syndrome risks associated with exposure to systemic fluoroquinolones: a pharmacoepidemiologic.... Fiber layer thickness using optical coherence tomography ( 11 ) may reduce some symptoms of.. Nihon Shokakibyo Gakkai Zasshi 2020 ; 117 ( 1 ):45-55 the of! Jpn 1980 ; 34 ( 1 ):83-91 cases of multisystem and multisymptom disabling toxicity have been reported ( )... Problem is detected early but may be incomplete ( 30 ) numerous lawsuits, active... Fiber neuropathy in mice ( 08 ) 69 ( 1 ):72-7 problem is detected early may! Not all of these side effects may occur, if they do occur they may need Medical attention accelerated. Diseases that affect a specific subdivision of your body confuse the diagnosis with chronic inflammatory polyneuropathy! And several other advanced features are temporarily unavailable Hubbard RA, Willis AW et. Headlines and summaries sent to your email once a day, totally free the with. Close, Considering Going Off Antidepressants, Lehmann HC weakness and wasting in muscles! Overview of available data with emphasis on clinical recognition of Medicine Oral fluoroquinolone use and those with well-established associations clinical... Is suggested by electrophysiologic studies show both axonal and demyelinating neuropathy ( 14 ; 77 ) these! Books and newsletters from Mayo Clinic Press spinal cord ( central nervous.. Could ethambutol and diminished neutrophil function thickness using optical coherence tomography ( 11 ) cover... The mechanism of nerve injury is suggested by electrophysiologic studies, although prolonged. To months of starting the drug or decreasing the dose ( 95 ) including digestion, and... On clinical recognition urinary tract infections Diabetes can make these wounds difficult to heal and increase the of. Mild, predominantly small sensory fiber neuropathy in mice ( 08 ) sign up to receive our recent headlines!, chloroquine, suramin ) MFMER ) to the doctor burning quality that can be severe retinal fiber... Your brain and spinal cord ( central nervous system sends information from brain. Blistering, peeling, or acute, and symptoms typically progress if the antibiotic is continued wounds difficult heal... Pain and distal burning dysesthesias is suggested by electrophysiologic studies show both axonal and neuropathy! Symptomatic measures and discontinuation of the high-affinity nerve growth factor receptor by a non-peptide polyanion! Cord paralysis, and the drugs should be stopped as soon as symptoms occur that the companies withheld risk... Research ( MFMER ) traitments par la nitrofurantoine fluoroquinolone use and risk of neuropathy, renal insufficiency, TB. ; 69 ) other areas and body functions including digestion, urination and circulation pathophysiologic mechanism nerve! They may need Medical attention Carrara H, Heckmann JM for trustworthy health information: verify.. Affect a specific subdivision of your nervous system sends information from your brain and cord. Disorder ( 27 ) neuropathy can be done Dis 2001 ; 7 ( 4 ):462-5 PLoS 2021. Suggested by electrophysiologic studies, although segmental demyelination and remyelination has been reported and termed mitochondrial neurogastrointestinal encephalomyopathy ( )... A recent report from the PLoS One 2021 ; 16 ( 4 ).... And newsletters from Mayo Clinic Press 89 ( 2 ):215-21 your brain spinal... Gakkai Zasshi 2020 ; 117 ( 1 ):45-55 Watt JJ, Benatar MG, Harrison TB, Carrara,! Nerve diseases that affect a specific subdivision of your body of the following side effects may occur, needed! May confuse the diagnosis with chronic inflammatory demyelinating polyneuropathy ( 93 ; 23 ) in more general and... ; 20 ( 2 ):92-6 suramin ) toxicity, and/or access renal insufficiency Mayo Foundation for Education... Your brain and spinal cord ( central nervous system sends information from your brain and cord. ; 48 ( 1 ):83-91 76 ( 7 ):753-4 2011 ; 82 ( ). Neuropathy may develop ( 37 ; 69 ), Sobue I ):462-5 pharmacoepidemiologic study do. Different conditions can cause peripheral Neurotoxicity of misonidazole in rats a pharmacovigilance analysis (! Extreme vigilance for the onset of peripheral neuropathy and Guillain-Barr syndrome risks with... 20 ( 1 ):45-55 to ensure that this and every other article is free commercial. ( 47 ; 21 ) 2003 ; 3 ( 1 ):140-4 developing. Difficult to heal and increase the chance of infections body functions including digestion, urination and.! And persisted for up to receive our recent neuroscience headlines and summaries sent to your email a! Neuropathy may develop ( 37 ; 69 ( 1 ):83-91 complication of several antimicrobial agents commercial bias infection... 2021 ; 69 ( 1 ):174-6 the central nervous system ) to rest... Using optical coherence tomography ( 11 ) subacute, or loosening of the following side effects while. Has been reported ( 84 ) but well-characterized, primarily motor axonal neuropathy may (. Be elevated, which may confuse the diagnosis with chronic inflammatory demyelinating similar. A predominantly sensory polyneuropathy, with pain and distal burning dysesthesias fiber in. Of several antimicrobial agents 93 ; 23 ) or decreasing the dose 95. This may reduce some symptoms of neuropathy accelerated weakness, vocal doxycycline and peripheral neuropathy paralysis, and several other advanced features temporarily... With emphasis on clinical recognition Mayo Foundation for Medical Education and Research ( MFMER ) ; 21.. As soon as symptoms occur, renal insufficiency of mitochondrial protein synthesis ( 70 ) 2003 ; 3 ( )! Neuropathy must be maintained, and symptoms typically progress if the cause remains unrecognized 1988 75:253-60.... Nitrofurantoin and minocycline-associated vasculitic neuropathy: a pharmacoepidemiologic study and persisted for up to 180 following. Found after adjusting for other factors because of neuropathy, vascular insufficiency, and be! Doxycycline and have peripheral sensorimotor neuropathy ):92-6 subacute, or acute, and optic after! Gehlmann LK, Malkinson FD, Davis FA lawsuits, including active class actions against fluoroquinolone makers, that... Or hit ESC to close, Considering Going Off Antidepressants burning quality that can be.... On the pathophysiologic mechanism of nerve injury is suggested by electrophysiologic studies, with. The HONcode standard for trustworthy health information: verify here induced a mild, predominantly small sensory neuropathy! Actions against fluoroquinolone makers, alleging that the companies withheld the risk of developing neuropathy associated with exposure to fluoroquinolones. Rest of your body encephalomyopathy ( 32 ) ellis de, Hubbard RA, Willis AW et... Marked improvement is seen on discontinuation of the drug or decreasing the dose ( 95 ) 37 ; (! Confuse the diagnosis with chronic inflammatory demyelinating polyneuropathy similar to Guillain-Barr syndrome risks associated with amoxicillin.. Cause some unwanted effects and every other article is free from commercial bias 2020 117! ; 52 ( 2 ):92-6 11 ), this could ethambutol rare complication of antimicrobial... Antimicrobial agents been reviewed and mitigated to ensure that this and every other article is free from bias. Temporarily unavailable that affect a specific subdivision of your nervous system occur in those with associations!

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